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Senior J, Delgado C, Fisher D, Tilcock C, Gregoriadis G

doi:10.1074/jbc.RA119.009879 54

Such an increase in the mRNA levels of the catalytic subunit of -GCS was paralleled by a greater mucosal synthetic GSH capacity determined from either cysteine or -glutamylcysteine used as the sulfur aminoacid in the presence of glycine and glutamate and ATP as described (Fernndez-Checa and Kaplowitz, 1990), indicating an increase in the activity of -GCS following TNBS+ethanol administration (not shown)

However, when the generation of ROS exceeds the level of antioxidant molecules in the heart, oxidative stress arises, which results from heart failure, cell death, hypertrophy, ischemia-reperfusion injury, and cardiac dysfunction

Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis

Reference Schwarz, Eno, Freitag-Pohl, Coxon, Straker, Wortley, Hughes, Mitchell, Moore, Cummins and Onkokesung2021
