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In mitochondrial diseases, CoQ 10 deficiency can primarily be caused by mutations in the genes responsible for CoQ 10 biosynthesis, or secondarily by defects in other genes [143]

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Probably the most prominent metabolic contributor to muscle loss with disuse is the resistance of muscle to anabolic stimulation

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doi: 10.1016/j.brainresbull.2009.05.019

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