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Eur J Biochem 270: 45154522

Wong HS, Dighe PA, Mezera V, Monternier PA, Brand MD (2017) Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

Our group have shown that quenching ROS through either genetic manipulation (expressing peroxiredoxin-3) 160 or administration of chemical antioxidant 161 effectively rescued PD phenotypes in neuronal and Drosophila models, suggesting that ROS play a crucial role in LRRK2 pathogenesis

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Zinc finger proteins achieve precise transcriptional regulation by recruiting specific coregulators

Data were acquired in profile mode