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PMC8337113

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"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity." Nature

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Blocking NNMT can boost NAD productionenhancing cellular energy, improving mitochondrial function, and accelerating the breakdown of fat

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The mouse studies ran for a matter of weeks before changes in body weight and fat mass appeared

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Unlike peptides, this compound is not composed of amino acid chains and is produced via chemical synthesis rather than peptide assembly

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These findings suggest that NNMT inhibition may modulate the metabolic responses to physical activity by altering cellular energy metabolism across multiple tissue types

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