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PMC8337113

"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity." Nature

Blocking NNMT can boost NAD productionenhancing cellular energy, improving mitochondrial function, and accelerating the breakdown of fat

The mouse studies ran for a matter of weeks before changes in body weight and fat mass appeared

Unlike peptides, this compound is not composed of amino acid chains and is produced via chemical synthesis rather than peptide assembly

These findings suggest that NNMT inhibition may modulate the metabolic responses to physical activity by altering cellular energy metabolism across multiple tissue types
