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A Phase I/II Study of the Combination of Oral Rigosertib and Azacitidine in Patients with Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML)

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[DOI] [PubMed] [Google Scholar] 121.Lopes da Silva S., Vellas B., Elemans S., Luchsinger J., Kamphuis P., Yaffe K., Sijben J., Groenendijk M., Stijnen T

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in this way, it plays a key role in the development of myocardial dysfunction ( Fine particulate matter (PM2.5) can produce a large number of ROS and reactive nitrogen species (RNS), caused the unbalance of cell homeostasis and then excessive ROS may result in damage of nuclear DNA and mitochondria including mitochondrial permeabilization, membrane potential decreasing and mitochondrial swelling, followed by further apoptosis in cardiomyocytes (Yang et al., 2018)