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An alternative folate- and vitamin B12-independent reaction utilizes betaine (a metabolite of choline) as the methyl donor to convert homocysteine to methionine

126 Furthermore, Kaur et al 127 proposed that the entry of SARS-CoV-2 facilitated by nsp14 protein in the host cell allows the use of cell S -adenosylmethionine for viral RNA capping, culminating in an increase in the Hcy production and angiotensin-converting enzyme-2 activation, which will facilitate greater viral entry into cells

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