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doi: 10.3389/fphys.2025.1586888 Received 03 March 2025 Accepted 19 May 2025 Published 02 June 2025 Volume 16 - 2025 Edited by Ahmad Alkhatib, Birmingham City University, United Kingdom Reviewed by Mohamed Elloumi, Prince Sultan University, Saudi Arabia Piyawan Bunpo, Chiang Mai University, Thailand Updates Copyright 2025 Wu, Chen, Zhao, Liu and Jiang

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AdoCbl binding allosterically affects BV affinity, with the BV dissociation constant decreasing ~10-fold from K d ~ 7 M to ~0.7 M in the presence of AdoCbl (Fig