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Frequency varies based on individual needs and clinical context

In cerebral malaria, a double-blind trial has shown that the use of corticosteroids is associated with prolonged coma and with a higher incidence of gastrointestinal bleeding and pneumonia

Functions through direct binding to PPARd ligand-binding domain, modulating gene transcription via PPAR response elements (PPREs)

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This makes IV therapy particularly attractive for individuals dealing with multiple concerns at once