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By targeting hypoxia of TME immunosuppression, MnO 2 NPs can exert their peroxide-like activity to react with tumor endogenous H 2 O 2 , which could generate in situ O 2 to relieve TME hypoxia to remit the immune suppression in solid tumors (33, 81)

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Microvascular porcine model for the optimization of vascularized composite tissue transplantation

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10.3390/ijms141121215 197 XieL.XieL.BourneP

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