glutathione-dependent detoxification pathway The proposed mechanism of 3HP detoxification. Red Glutathione Metabolism and Its Implications

GSH depletion causes ferroptosis in RPE cells To evaluate the mechanism of cell death in GSH-depleted cells, we treated RPE cells with various cell death pathway inhibitors including ferroptosis inhibitors ferrostatin-1 (Fer-1, 8 M), liproxstatin-1 (Lip-1, 600 nM), iron chelator deferoxamine (DFO, 80 M), pan-caspase inhibitor z-VAD-fmk (30 M) to inhibit apoptosis, autophagy inhibitor 3-methyladenine (3-MA, 10 mM), and lysosomal inhibitor bafilomycin A1 (Baf-A1, 75 nM)

Those with obesity and metabolic syndrome have a higher prevalence of vitamin D deficiency and inflammation

doi: 10.1002/smll.200500105

Byrnes CA

[ [PMID: 15082137]

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