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doi: 10.1258/acb.2011.011039
Expires after 12 months
Elevates NAD+ and S-adenosylmethionine (SAM) levels, shifting metabolic flux toward energy expenditure and away from fat storage 1-4
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AOD-9604 was subsequently placed in Category 2 of the bulk drug substance nomination list, then later withdrawn from that nomination in April 2026
The combination of reduced intake and impaired absorption creates a trajectory toward deficiency over months and years of treatment
