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doi: 10.1074/jbc.M405635200 81 WyllieS.VickersT

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On one hand, TMAO may exacerbate neuroinflammation by influencing the activation state of microglia and the phenotypic transformation of monocytes and astrocytes, rendering them more susceptible to a pro-inflammatory phenotype, which leads to the secretion of elevated levels of inflammatory mediators such as IL-6 and MMP-9 (Haghikia et al., 2018

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Urate, also known as uric acid, is a major endogenous antioxidant that is neuroprotective against both astrocyte-induced toxicity in SOD1 G93A mice and H 2 O 2 induced oxidative stress in cells expressing mutant SOD1 G93A (Bakshi et al., 2018)