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While these experiments uncovered more information about cellular changes due to deletions of copies of the S-Adenosylmethionine synthetase genes, SAM1 and SAM2 , additional work was needed to try to identify how these mutations, and the resultant alterations in AdoMet concentration, led to the various differences that were observed

doi: 10.1369/0022155419859870 34 SenguptaA.BabaK.MazzoniF.PozdeyevN

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Psychopharmacology (Berl) 181, 722734

The epimerase catalyzes at least two distinct epimerization reactions on the GDP-D-mannose substrate (Wolucka and Van Montagu, 2003), and releases, in addition to the well-known GDP-L-galactose, two additional products GDP-L-gulose and GDP-D-altrose in an equilibrium ratio of 72:20:4:4

FIGURE 1 A comprehensive literature search was undertaken across major global and regional electronic databases (PubMed, Web of Science, CNKI, Google Scholar) from their respective inceptions to April 2025, employing a combination of Medical Subject Headings (MeSH) terms, keywords, and Boolean logic combinations (e.g., Hippophae rhamnoides AND phytochemistry) for systematic retrieval of relevant studies