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Histological analysis revealed a significant reduction in the number of Nissl bodies and dopaminergic neurons in the substantia nigra and striatum of Nrf2-deficient mice, suggesting more severe neuronal damage and death

methylenedioxyl (OCH 2 O)

10.14336/ad.2017.0829 65 LiangK

Findings from a population-based study mirror some of those from preclinical data obtained from an in vivo study

Ann Thorac Surg (2002) 74:15537

Unless the drug candidate is intended for woman's health, typical FIH studies enroll male volunteers and sometimes include women of nonchildbearing potential, due to concerns about potential adverse embryo/fetal effects of treatment