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[DOI] [PubMed] [Google Scholar] Sarmento B, Martins S, Ferreira D, Souto EB

Since aging is a multifactorial and highly complex biological process, many factors including genetic mutations, epigenetic alterations and metabolic dysregulation play a significant role in the process

Research from the University of Michigan's Department of Gastroenterology found that excessive antioxidant supplementation

The MTHFR gene provides instructions for making the MTHFR enzyme (methylenetetrahydrofolate reductase) that helps convert folate (vitamin B9) into its active form: L-methylfolate.* This active folate is the key ingredient in producing methyl groupstiny chemical tags that your body uses in dozens of reactions, including: DNA repair, neurotransmitter synthesis, hormone metabolism, cardiovascular support, and detoxification.* The whole process is called methylation, and without enough methyl groups, your bodys cellular cleanup crews start falling behind on their tasks.* Detox Pathways That Depend on Methylation Methylation affects detox in two major ways: Breaking Down Hormones Estrogen, for example, requires methylation for efficient breakdown and elimination