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Early therapeutic efforts using muscarinic receptor agonists like xanomeline were limited by peripheral side effects

MTHFR is a key enzyme in folate metabolism

This fundamental difference drives the efficacy gap

1967 [PMID: 4143721 DOI: 10.1016/s0140-6736(67)90168-7] [PubMed] [Google Scholar] 6.Villar J, Blanco J, Kacmarek RM

doi: 10.1111/j.1365-2567.2009.03225.x 135 MengFXHouJMSunTS

This review provides an overview of berberine in neurodegenerative diseases and its related mechanisms, and also provides new ideas for future research on berberine
