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Week 1: 50mcg nightly Week 2: 100mcg nightly (if Week 1 tolerated well) Weeks 3-4: 150mcg nightly (if no adverse effects) Weeks 5-8: 200-300mcg nightly (target maintenance dose) Gradual titration helps identify your minimum effective dose while avoiding unnecessary exposure to higher amounts

BMC Bioinformatics

Zinc plays a role in the metabolism of thyroid hormones by regulating deiodinase enzymes, and also plays a role in the synthesis of thyrotropin releasing hormone (TRH) (31), secreted from the hypothalamus and TSH (in the pituitary gland)

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doi: 10.1007/s11916-004-0022-z [DOI] [PubMed] [Google Scholar] 29.Sparaco M, Feleppa M, Lipton R, Rapoport A, Bigal M

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