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DRUG INTERACTION Pyridoxine (Vitamin B6) reduces therapeutic effect of levodopa but it does not occur if a dopa decarboxylase inhibitor is also given

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In a 9-month monkey oral toxicity study, all female monkeys in the high-dose group showed minimal-to-slight periportal hepatocyte vacuolation
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Restricted dietary intake of B12 is associated with veganism and to a lesser extent vegetarianism, dietary patterns that avoid all or certain animal-source foods, respectively
