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To improve therapeutic index and minimize drug product heterogeneity, a recent study by Procopio-Melino et al

Patients experiencing grade 2 stomatitis (painful erythema, edema or ulcers of the mouth or tongue, but able to eat) or greater should be instructed to stop taking XELODA immediately

Many patients pick the same time each week, such as Monday morning or Friday afternoon, so the visit becomes a simple habit

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In order to determine the low molecular weight sulfur-containing compounds by reversed phase high-performance liquid chromatography (RP-HPLC), the pellets were suspended in a 250 L mixture consisting of 0.9% NaCl (Sigma-Aldrich, Darmstadt, Germany)/1 mM bathophenanthrolinedisulfonic acid disodium salt hydrate (BPDS, Sigma-Aldrich, Darmstadt, Germany)/70% perchloric acid (PCA, Polish Chemicals Reagents, Gliwice, Poland)

Exhibit I also folds those studies into a broader literature review that includes retrospective human work in knee pain, interstitial cystitis, and intravenous infusion tolerability