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Peripheral serotonin synthesis as a new drug target

Sustained inflammatory insults induce cumulative DNA damage and epigenetic reprogramming, fostering malignant transformation through two synergistic mechanisms: (1) persistent immune cell activation (neutrophils, macrophages, lymphocytes) and (2) tumor co-option of inflammatory mediators (IL-6, TNF-, COX-2) as metastatic accelerants

doi: 10.1016/j.jns.2003.11.005

these include transient nausea and vomiting, abdominal cramps, and diarrhea

Therefore, in the present study, our purpose was to determine the impact of oral GPLC on plasma NOx at rest and in response to a period of reactive hyperemia in resistance trained men

However, further mechanistic studies and human intervention trials are needed to better elucidate the relationship between diet, microbiota-dependent TMAO production, and its impact on human diseases