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MC4R-expressing neurons in this region project to brainstem autonomic centers and interface with mesolimbic dopaminergic pathways the reward and motivation circuitry that underpins sexual desire

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Mol Pharmacol 64:94103 [DOI] [PubMed] [Google Scholar] Sebhat IK, Martin WJ, Ye Z, Barakat K, Mosley RT, Johnston DB, Bakshi R, Palucki B, Weinberg DH, MacNeil T, Kalyani RN, Tang R, Stearns RA, Miller RR, Tamvakopoulos C, Strack AM, McGowan E, Cashen DE, Drisko JE, Hom GJ, Howard AD, MacIntyre DE, van der Ploeg LH, Patchett AA, Nargund RP 2002 Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethylamine(1), a potent, selective, melanocortin subtype-4 receptor agonist