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Leaky guts: intestinal permeability and NASH

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While the impact of G6PD-d on these covariates has been discussed thoroughly in a previous review, we will summarize here for completeness 23

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S.AbassiT.et al (2013)

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Ann Hum Genet 49:267274

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689 Since eIF2 phosphorylation is a central event in the ISR, which is regulated not only by PERK but also by other stress-sensing kinases, therapeutic targeting of eIF2-P could unintentionally disrupt multiple essential cellular processes

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