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The degenerative process of intervertebral discs is often accompanied by the overexpression of matrix metalloproteinases (MMP3, MMP13) and inflammatory factors (IL-1, IL-6, IL-8, PEG2, TNF-) (Wang et al., 2020)

While IGF-1 LR3 was engineered for extended half-life and systemic activity, IGF-1 DES follows the opposite strategy: very short half-life (20-30 minutes) but extreme potency at the site of injection

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10.1016/j.jenvman.2020.111237 309 WatrasC