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It occurs naturally in the body, particularly in connective tissue and skin

4.2 Targeting mtROS to improve tumor immunotherapy Since ROS in tumor cell mitochondria have been shown to play an important role in immunotherapy, how mitochondrial targeted drugs can promote tumor cells to produce excessive ROS, damage mtDNA, release immunogenic intracellular substrates, and activate anti-tumor immunity are important areas of focus in anti-tumor research ( Figure 9 )

Am J Dermatopathol (2016) 38(5):33846

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