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Thats whats changed. FDA-approved peptide drugs such as insulin and oxytocin have been available for decades

In these ways, mitochondria contribute to various diseases, including tumors, cardiovascular diseases, neurodegenerative diseases, metabolic abnormalities, ocular diseases, liver diseases, and autoimmune diseases, by inducing mitochondrial dysfunction or through regulating oxidative stress, inflammation, and aging

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Coenzyme Q10 emerges as a potent antioxidant, safeguarding skin from oxidative stress and premature ageing

Common strategies to address this problem include introducing hydrophilic modifying groups (such as PEG chains), adjusting linker length to avoid steric hindrance affecting antibody binding, and selecting conjugation chemistries with appropriate reactivity (e.g., maleimidethiol coupling or click chemistry)