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Heart rate elevation and autonomic effects One of the most consistent physiological effects observed with GLP-1 RAs is a modest, dose-dependent increase in heart rate, typically ranging from 2 to 5 beats per minute

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41 Appendage of the amino acid sequences of either cagrilintide or pramlintide to the C-terminus of semaglutide resulted in significantly diminished potency at the AMYR, with a 2050-fold decrease compared to cagrilintide