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GHR-Mediated SRC Family Kinase (SFK) Signaling Src family kinases are non-receptor tyrosine kinases, which comprise nine members, namely, Src, Lck, Hck, Fyn, Blk, Lyn, Fgr, Yes, and Yrk, all of which share a common multidomain topology consisting of consecutive SH3, SH2, and SH1 KDs and a unique region located close to the N-terminus, which differentiates each member of the family

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Mitochondrial dysfunction results in increased production of ROS which activates stress responses leading to increased activity of MAPK and JNK

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