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For transgenic constructs that did not yield stable extrachromosomal arrays after three independent trials, the plasmid was linearized by restriction enzyme digestion and amplified from promoter to 3UTR

(61) demonstrated that combined L-carnitine and nicotinamide riboside administration upregulated multiple metabolic and insulin signaling regulators ( Ppargc1b, Acox1 ), promoting mitochondrial oxidative phosphorylation and peripheral glucose uptake

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Zesiewicz, Theresa A.|Sullivan, Kelly L.|Maldonado, John L.|Tatum, William O.|Hauser, Robert A

S., Baek J

doi: 10.1016/j.bbalip.2007.04.003