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This complex metabolic disorder is accompanied by an increase in local and systemic inflammatory mediators, such as proinflammatory cytokines [e.g., interleukin (IL)-6 and IL-8 and tumor necrosis factor-alpha (TNF-)] [9, 10]

This review systematically summarized LC-associated psychological symptoms, including social stigma and shame, anxiety and depression, PTSD, fatigue, sleep disturbances, and cognitive dysfunction, all of which significantly reduce patients quality of life and social functioning

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Wang J., Long C., Zhang H., Zhang Y., Wang H., Yue H., Qi G

Chronic exposure to Nusinersen restored SMN expression and led to a significant upregulation of SNAT5, along with a reduction in GAT3 and a concomitant increase in GABA levels

doi: 10.1016/s0005-2760(98)00056-3

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