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Combined with reduced caloric intake from appetite suppression, the caloric deficit expands significantly

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[DOI] [PubMed] [Google Scholar] 32.Perez-Garcia A, Hurtado-Carneiro V, Herrero-De-Dios C, Dongil P, Garcia-Maurino JE, Sanchez MD, et al

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Signs of significant dehydration that you cannot correct with fluids, or a sustained heart rate jump well beyond the expected range, also warrant a conversation