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As pointed out [60], it has to be the counteraction of the reduced capillary perfusion pressure, increased cerebral blood volume, venous flow obstruction, increased intracranial pressure and blood-brain barrier disruption, resulting in a decreased cerebral blood flow [60]

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178 In addition, it was found that TRPV1 genetic deletion, inhibition, or desensitization in mice decreased the activity of osteoclasts in vitro and inhibited ovariectomy-induced bone loss as well as osteoporosis in vivo

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Garca-Montero C, Fraile-Martnez O, Gmez-Lahoz AM, Pekarek L, Castellanos AJ, Noguerales-Fraguas F et al (2021) Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay

In addition, some studies have indicated that the effect of the compound on inhibiting ferroptosis is related to SLC7A11, but the specific regulatory mechanism is not clear