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| | Intensive Performance Protocol | 10mg subcutaneous, 5x/week (weekdays) | 150mg oral, daily | Both compounds AM, pre-training | 6 weeks on, 4 weeks off | Athletic performance research, substrate utilization studies, endurance capacity trials | Higher dosing frequency and dose intensity produce more pronounced short-term shifts in RER and VO2 max, but require stricter adherence and increase washout sensitivity

Phase 2 trials ran 12 weeks (METAOD005) and 24 weeks (METAOD006/OPTIONS)

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Often, once injections start, patients discontinue separate oral B supplements, sticking to perhaps just a basic multivitamin or prenatal vitamin at most

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This 5mg presentation offers precise measurement capability for controlled in-vitro and preclinical investigative applications