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Drug-by-Drug Side Effect Profiles# Semaglutide (Wegovy/Ozempic)# Semaglutide is the most extensively studied GLP-1 agonist, with GI data from the STEP program (obesity) and SUSTAIN program (T2D)

A proteolytic enzyme, dipeptidyl peptidase-4 (DPP-4), binds to and destroys GLP-1 molecules in the blood in minutes
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[DOI] [PMC free article] [PubMed] [Google Scholar] 184.Wang KL, et al

B12 absorption is particularly affected
