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doi: 10.1016/j.plipres.2005.05.001

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About Diagnosis depends on family history and the presence of six or more caf-au-lait spots (larger in 5mm in children or 15mm post-puberty) two or more neurofibromas or one plexiform neurofibroma freckles in the underarm or groin area an optic nerve glioma two or more Lisch nodules bone changes Your doctor may consider an NF1 diagnosis if you have: a family history of NF1 and one or more of these symptoms no family history of NF1 and two or more of these symptoms However, your doctor must also rule out other diseases that can cause tumors

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