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Three trials that compared ALCAR treatment (1-3 g/day for 7-12 weeks) and antidepressant medications found ALCAR was as effective as antidepressants in treating depressive symptoms (95)

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10.3892/mmr.2021.12337 39 MagistrelliL.StorelliE.RasiniE.ContaldiE.ComiC.CosentinoM.et al (2020)

Similarly, enhanced expression of GRP78, PERK, ATF4, and XBP1 exacerbates renal dysfunction during IRI (192)

However, fasting for 510 days caused an oxidative shift in rat soleus skeletal muscle and heart total NADPH/NADP + (Ibrahim et al., 2020), while rat skeletal muscle pyruvate/lactate was either unchanged (Ibrahim et al., 2020) or slightly oxidized depending upon the type of skeletal muscle, the age of the animal, or the duration of the fast (Fagan and Tischler, 1986)