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Cysteinylglycine or -glutamylcysteine have been proposed as possible alternatives.In a trial of adolescents with poorly controlled type 1 diabetes, a dose of 30-45mg/kg/day NAC failed to correct several markers of glutathione status, suggesting either a higher dose or alternative therapies may be indicated in this population.A recent study of patients with poorly controlled type 2 diabetes found that dietary supplementation of the amino acids cysteine and glycine, markers of glutathione synthesis and plasma oxidative stress were both improved

Biological function GST in metabolite detoxification and antioxidation The classical view holds that as a dimeric isoenzyme, GST can conjugate GSH with substrate molecules in efforts to promote clearance of active ionic substances

Retinoids, LRAT and REH activities in eggs of Japanese quail following maternal and in ovo exposures to 3, 3, 4, 4-tetrachlorobiphenyl

An in vitro study also has shown that riboflavin depletion in intestinal cells could lead to overproduction of ROS in these cells (Reference Lee, Corfe and Powers46)

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Study exclusion criteria may have selected patients at lower risk of overdose, and substantial loss to follow-up (approximately 80%) also may have biased estimates