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doi: 10.1007/s12026-016-8817-7 97 HelbigKJHeatleySLHarrisRJMullighanCGBardyPGMarmionBP

Christie MJ: Cellular neuroadaptations to chronic opioids: Tolerance, withdrawal and addiction

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Combination therapy and precision medicine N-acetylcysteine (NAC) The antioxidant NAC attenuates oxidative DNA damage by ROS and replenishes the levels of intracellular glutathione, a key antioxidant involved in DNA repair (Table II) (205)

Common side effects include dry mouth, insomnia, increased heart rate, elevated blood pressure, constipation, nervousness, and headaches

Sulforaphane also reduced the expression of MDA and enhanced that of antioxidant enzymes concentration-dependently, in part by promoting the phosphorylation of the antioxidant transcription factor Nrf2 [153]
