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Direct mechanical exposure initiates hepatocyte proliferation

For instance, the majority (58%) of mouse microbiome studies published in 20182019 did not report the number of mice per cage, and less than 20% of studies reported using singly-housed animals 64

62 reported that ERS was observed in mice 12 h after APAP treatment, and APAP evidently induced liver injury by activating CHOP

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Microbial diversity, the bacteria that live in the mucus layer, and the metabolites they release all shape how well the epithelium holds together and how the immune system responds