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However, its efficacy is often hampered by inherent or acquired radiation resistance in tumors

Similarly, bilayer wound dressings , such as asymmetric polycaprolactone (PCL)hydrogel constructs, demonstrate how spatially organized scaffold architectures can facilitate sequential control over hydration, antioxidant release, and tissue regeneration, reinforcing the value of spatiotemporal design principles in regenerative biomaterials [20]

The same principle of using an immobilized substrate for enzyme purification was adopted for the enrichment of lipase by using powdered stearic acid, the purification of pepsin by employing edestin (a crystalline protein), and the isolation of porcine elastase by using powdered elastin [2427]

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In addition to components of the PDHc itself, mutations in the gene (PDP1) encoding one of the catalytic subunits of the major PDH phosphatase and mutations in the gene (PDHX) that encodes a E3 subunit binding protein, have been shown to be associated with PDH deficiency syndromes