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Some individuals require a session in a week and other may need less

Shear stress, hypoxia, or pharmacological stimuli, such as -adrenergic receptor stimulation, have been shown to activate signaling cascades leading to release of ATP through cystic fibrosis transmembrane conductance regulator or pannexin 1 channels (36, 53)

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Spicer J, Rice R, Shewale J, Sepesi B, Antonoff M , Walsh G, Swisher S, Estrera T, Safi H, Khalil K

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Procedures were in line with the standard operating procedures (SOPs) of the Animal Pharmacology Facility, and the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (ETS 123)