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Free vitamin C (ascorbic acid) did not protect against liver or kidney damage in mouse models (Jonker 1988

The results showed that stimulation of OT-1 (transgenic CD+) T cells with OVA antigen resulted in activation, as shown by a decrease in the surface expression of CD62L which coincided with significant apoptosis measured three and five days after antigen stimulation

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Moreover, transcription factors like the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), the myocyte enhancer factor 2 (MEF2) and activating transcription factor-2 (ATF-2) work together to promote PGC-1 expression [17]

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Metabolomic evidence for peroxisomal dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome