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In addition, NAD has recently emerged as a crucial regulator of signaling pathways implicated in multiple physiological conditions [112]

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The two main signaling roles of NAD include its importance as a substrate for the generation of second messengers such as cyclic-ADP-ribose (cADPR) [19] and its role as a substrate and regulator of the NAD dependent deacetylases sirtuins [1012]

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