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Disturbances of AAs may serve as AF biomarkers, and restoring their homeostasis may have potential benefits for the management of age-related AF

Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin

Trauma Traumatic brain injury is relatively common in childhood with ~180 children per 100,000 population sustaining a closed head injury each year

Studies suggest that interventions such as antioxidant-rich diets, sleep-enhancing drugs, and exercise can improve mitochondrial function, mitigate oxidative damage, and promote healthier aging

They propose a staging system that takes into account these anchors, and starts from Stage 0, preclinical disease, defined by the presence of fully penetrant SNCA variants