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(vii) reduce the production/secretion of tumor necrosis factor alpha (TNF-), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1/CCL2), plasminogen activator inhibitor type 1 (PAI-1), transforming growth factor beta-1 (TGF-1) and angiotensinogen, while it can stimulate the secretion/activity of adiponectin

That study enrolled 3,417 adults with obesity or overweight and without type 2 diabetes, and showed a mean weight loss of 22.7% at 68 weeks in patients who remained on treatment

Mongraw-Chaffin ML, Anderson CA, Allison MA, Ouyang P, Szklo M, Vaidya D, Woodward M, Golden SH

These drugs' weight-loss effects make them an appealing alternative for both patients and healthcare practitioners

Easy as 1-2-3

While GLP-1RAs have been linked to a statistically significant elevation in the risk of early-stage DR events compared to placebo, they may conversely demonstrate a protective effect against the progression to advanced-stage diabetic retinopathy when compared to insulin therapy [81]