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PIEZO1 ion channel mediates ionizing radiation-induced pulmonary endothelial cell ferroptosis via Ca2+/calpain/VE-cadherin signaling

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Nolan, G

Consistently, baseline leukocyte DNA methylation (including global indices) predicts MTX non-response in early RA, while multiple cohorts reveal methylation signatures associated with MTX response, pointing to a pharmaco-epigenetic interface between folate metabolism and RA therapy (125-127)

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Therefore it is essential to investigate the effect of GSH depletion on RPE cells to further elucidate the potentially involved mechanisms