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Another study [576] investigated the effects of SM and L-arginine (L-Arg) on IBD progression in a TNBS-induced colitis rat model, finding that both treatments ameliorated colitis symptoms, decreased serum TNF- levels, inhibited colonic iNOS, NF-B, and cytochrome c expression, and increased HSP70 expression
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(2024) revealed that CYP2C19 poor metabolizers exhibited a higher remission rate compared to normal metabolizers (OR = 1.46
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