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Although many studies have investigated various oral supplements and medications, such as vitamin E, Potaba (potassium amino-benzoate), tamoxifen, colchicine, and carnitine, none have demonstrated significant benefits in randomized controlled trials, and scientific data do not support the use of these agents

27 , e930886 (2021)

131,132 A 14-month randomized controlled trial that included 74 participants with biopsy-diagnosed NAFLD found melatonin, at 5 mg twice daily, reduced inflammatory cytokine levels, as well as GGT, triglyceride, and LDL-cholesterol levels

when used in excess or consumed too rapidly, caffeine can cause anxiety, rapid heart rate, chest pain, heart problems, dizziness, and tremors

For example, the lack of muscular control can occur during wakefulness in a cataplexy episode

10.1111/j.1471-4159.2006.04406.x 23 Cunha-OliveiraT.RegoA