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Clinical Research Findings: SUSTAIN and PIONEER Trials A comprehensive safety analysis of 11,159 patients with type 2 diabetes across the SUSTAIN and PIONEER phase IIIa clinical trial programs found that gastrointestinal disorders occurred in 41.9% of patients receiving subcutaneous semaglutide and 39.1% receiving oral semaglutide, compared to 22.0% and 24.8% in comparator groups, respectively

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10.1002/art.21239 77 ShangJ.XiongC.JiangW.YuZ.ZhangJ.ZhangY.et al (2025)

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[74] at the University of Auckland considering almost 20 studies and a quarter of a million children less than 2 years of age raised no substantial flags concerning the safety of early exposure to APAP

The cycles overlap for the first 2 months