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It has been shown that metformin, in addition to its proven efficacy as a hypoglycemic agent, can exert multiple anti-aging effects at the cellular and tissue levels is also a traditional CRM (Solymar et al., 2018)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 167.Mackness MI, Arrol S and Durrington PN

Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins

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(A-C) Effect of variations in and under normoxic conditions ( = 164mM)