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EGF (Epidermal Growth Factor) and sh-Oligopeptide-1: the keratinocyte signal Epidermal growth factor was identified in 1962 by Stanley Cohen at Vanderbilt, work that earned the Nobel Prize in 1986

The finding that the injection of GSH itself did not blunt the ventilatory depressant effects of fentanyl raises the tentative suggestion that the bioactivity of GSHee may be due to the enhanced ability of the thiolester to enter cells that control breathing and that this intracellular entry is related to the sustained efficacy of GSHee against some of the actions of fentanyl

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Implications: Reframing the ASI as a measure of resilience highlights its potential as a research framework for investigating endocrineimmune adaptation